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Thus, opioids should be used as briefly as possible, and in dependent patients, the dose should be tapered to control withdrawal symptoms when opioids are no longer necessary
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clEDS is caused by homozygous or compound heterozygous pathogenic variants in the TNXB gene, which leads to nonsense-mediated mRNA decay of TNXB and result in complete absence of TN-X or in misfolding of the protein8
