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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]
In clinical trials, 6-16% of participants discontinued retatrutide due to gastrointestinal adverse events (Jastreboff et al., NEJM, 2023)
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In women, cycle length variability fell and luteal progesterone increased in small cohorts
