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Beyond the immediate nerve injury, the surgical environment itself contributes through associated factors like the intensity of acute postoperative pain, which acts as a potent nociceptive barrage driving central sensitization, and potentially inadequate perioperative analgesia [4]

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Abbreviations ASD: Autism spectrum disorder C1: One-carbon CFD: Cerebral folate deficiency CNS: Central nervous system DA: Dopaminergic FOLH1: Folate hydrolase 1 FR: Folate receptor FR: Folate receptor FR: Folate receptor FR: Folate receptor FRAAs: Folate receptor autoantibodies bFRAAs: Blocking autoantibodies to folate receptor GPI: Glycosylphosphatidylinositol MTHFR: Methylenetetrahydrofolate reductase 5-MTHF: 5-Methyltetrahydrofolate NMDA: N-methyl-D-aspartate Pax3: Paired box 3 PCFT: Proton-coupled folate transporter RFC: Reduced folate carrier SCF: Cerebrospinal fluid TRP/TRPM: Transient receptor potential superfamily, melastatin-related subfamily References Saitsu H (2017) Folate receptors and neural tube closure