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5) Medication Several drugs can increase homocysteine levels, including: Methotrexate, an immunosuppressant [19, 20] Metformin, used in diabetes [21] Cholestyramine, used to lower cholesterol [22] Antiepileptics [23, 24, 25] 6) Kidney Disease Kidneys help transform homocysteine into other amino acids [26]

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