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These imbalances are associated with reduced GSH levels, a lower overall antioxidant capacity and the activation of nuclear factor kappa B (NF-B), a transcriptional factor for inflammatory pathways (Naik et al., 2011)

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Subsequently, a lack of saliva induces xerostomia, mucositis, nutritional deficiencies, oral infections, and functional changes (such as difficulties with mastication, dysphagia and loss of taste) (16, 17)