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Sulfa allergy is caused by the nitrogen containing heterocyclic ring and aryl-amine moiety
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doi: 10.1016/j.ejca.2012.05.015 185 XiongDChenYZhuSLiuLZhaoLZengCet al
Of the three haplotypes, the upstream genetic alterations that were in linkage disequilibrium with the Leu allele were also found to have the lowest level of activity in a transcription reporter gene assay, causing a 25% suppression in promoter activity (152)
