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Stout et al

Increased levels of isoprostanes, and predominantly 8-iso-prostaglandin (8-iso-PGF2) have been detected in the urine of patients, making analysis of isoprostanes a valuable and reliable marker of the level of oxidative damage in schizophrenia patients (De Simone et al
doi: 10.1089/thy.2020.0299 207
In animal reproduction studies, intravenous administration of pemetrexed to pregnant mice during the period of organogenesis was teratogenic, resulting in developmental delays and increased malformations at doses lower than the recommended human dose of 500 mg/m2
