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Experimental evidence indicates that ironrich EVs promote syn aggregation and enhance inflammatory responses by glial cells [142]
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In 2009, one study using FDG-PET found that PD patients had significantly higher normalized brain metabolic rates of glucose in the bilateral globus pallidus and SN, contralateral caudate nucleus, and ipsilateral putamen relative to the clinically most affected body side, compared to healthy subjects [35]
doi: 10.1074/jbc.M303423200
