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Heme groups consist of a central iron atom in a coordinated binding to a protoporphyrin, composed of four pyrrole rings

we observed a 11.7-fold change for venetoclax, a 18.4-fold change for AZD-5991, and an 5.5-fold change for ibrutinib

Therefore, DHODH has emerged as a potential regulatory hub, where its inhibition may enhance ferroptotic cell death, offering a novel angle for therapeutic intervention, particularly in cancers such as pancreatic adenocarcinoma (175) and breast cancer (176), where certain cells show resistance to other forms of cell death (171,177)

This study also reveals that Sel S interacts with Serum Amyloid A (SAA), an acute phase inflammatory response protein and provides a mechanistic link between Type-2 diabetes, inflammation and cardio vascular disorders