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BAY-1082439, a chemical molecule undergoing phase I clinical trials in patients with advanced cancer, can efficiently inhibit the expression of P-gp and BCRP by selectively inhibiting PI3K 110 and 110, and slightly suppress the efflux effect of P-gp and BCRP (118)

These findings potentially open the way for exciting future diagnostic/theranostic uses of this nanocarrier (Fig

Pande and Flora [69] reported that a combination of lipoic acid and thiol chelator was able to alleviate lead toxicity, and in particular, it reduced oxidative stress and lead levels in the brain

Furthermore, ER stress is acknowledged as a secondary consequence of metabolic dysfunction, frequently caused by the excessive buildup of reactive oxygen species (ROS) and disruptions in intracellular calcium levels