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10.3748/wjg.v25.i39.5897 129

In particular, the depletion of glutathione has been proposed as an early event prior to the initiation of apoptosis by oxidants inducing the ROS production, while the supplementation of glutathione has the effect of preventing such apoptosis [15,16,18]

They found that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration

, .