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Insulin resistance when the body's cells don't respond properly to insulinis often linked to high levels of oxidative stress

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Myristica fragrans (nutmeg) extract, acting through the Akt/JNKKeap1Nrf2HO-1 cascade, simultaneously reduced pro-inflammatory cytokines (TNF-, IL-1, IL-6) and oxidative stress markers (MDA, MPO), while enhancing IL-10, SOD, and GSH-Px activities ( Codonopsis pilosula (Dangshen) extract demonstrated dual regulation in a chronic obstructive pulmonary disease model: activating Nrf2 while suppressing NF-B, as indicated by reduced p-p65/p65 and p-IB-/IB- ratios, leading to improvements in both inflammation and oxidative stress ( in vivo (4 dpf zebrafish larvae) and in vitro (BV-2 microglial cells) models, by modulating the Nrf2 and TLR4 signaling pathways (Figure 3C) ( Overall, the anti-inflammatory mechanisms of phytochemicals are inherently multidimensional, operating through NF-B inhibition, MAPK modulation, and Nrf2 activation (Saleh et al., 2021