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For this reason, high-dose oral supplementation or alternative delivery routes are preferred: High-dose oral cyanocobalamin tablets (typically 1,000 micrograms daily) are the standard oral option in the UK

People, who have had bariatric surgery procedures such as sleeve gastrectomy, Roux-en-y gastric bypass, duodenal switch, one anastomosis (mini) gastric bypass, single anastomosis duodenal ileal switch (SADIS), have reduced absorption of vitamin B12 and increased risk of developing vitamin B12 deficiency

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A typical AOD9604 5mg vial reconstituted with 2mL sterile water provides a concentration of 2.5mg/mL, making a 500 mcg dose equal to 0.2mL (20 units on an insulin syringe)