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Commonly referenced guidance includes: Initial replacement Maintenance For maintenance, the BNF lists adult prophylaxis/maintenance dosing such as 1 mg intramuscularly every 23 months in appropriate cases

Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition