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Caloric restriction, improvements in metabolic health, and reductions in adiposity independently influence DNA methylation patterns and epigenetic aging metrics, making it difficult to isolate the specific contribution of nutrient composition or individual bioactive compounds [46,47]

We next wanted to investigate the contributions of IMSlocalized redox processes to E GSH [IMS] including the respiratory chain, antioxidative systems and the Erv1Mia40 machinery for protein oxidation (Figure 5C)

V.WebberL.et al (2018)