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Abstract Background Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER)

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This research discovered that acid condensation products of dietary indoles that can be observed in Figure 2C are the main culprit in the results observed, providing chemical structures with known function and structural characterization shown in Figure 2C ( In male diabetic Sprague-Dawley rat models treated with streptozotocin, increased FMO activity and was thus positively correlated with increasing blood glucose levels

Small-study effects were examined via funnel plots, Eggers regression, and Beggs rank test, with trim-and-fill used as sensitivity analysis when indicated