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Brand MD, Goncalves RL, Orr AL et al (2016) Suppressors of Superoxide-H(2)O(2) production at site I(Q) of mitochondrial complex I protect against stem cell hyperplasia and Ischemia-Reperfusion injury
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Indeed, it was recently reported that treatment of cells with H 2 O 2 , which can lower GSH levels, leads to increased expression of NRF2 target genes in a KEAP1-independent mechanism 69
Among them, several genes seemed to be involved in mitochondrial metabolism and oxidative stress, as e.g., SLC25A39
