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One of the hallmarks of the inactive X chromosome is the hypermethylation of promoter CpG islands along the length of the inactive X, which contributes to the stable maintenance of transcriptional silencing of the associated genes on the inactive X chromosome (72)
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they also impact neuronal function and survival
The changes in envelope lipidome remodelling, akin to that observed in some marine and terrestrial bacteria [1520] suggests that standard Mtb culture conditions that use media with high concentrations of Pi do not reflect the physiologic environment during infection, thereby potentially undermining vaccine and drug development for tuberculosis
