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In phase I, a explorative, single-blind, placebo-controlled study [260] was conducted to assess the safety, tolerability, and preliminary pharmacokinetics of BPC 157 in thirty-two healthy male volunteers (A placebo-controlled study to investigate the safety, tolerability and preliminary pharmacokinetics of PL 14736 in healthy male subjects

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Glutathione is the liver's major antioxidant, often depleted in fatty liver disease due to oxidative stress and inflammation

GR knockout seemed to affect these pathways particularly, hinting at a metabolic recalibration in response to the redox imbalance