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Eosinophil peroxidase (EPO) is highly basic, pI 10.8, localized in the matrix of the specific eosinophil granule and is a key participant in generating reactive oxidants and free radical species in activated eosinophils

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MPNSTs are currently untreatable, while only recently an inhibitor of MEK, a downstream effector of Ras signaling, has been approved for pediatric inoperable neurofibromas [2]

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