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[58] However, another study in 21 physically active men between the ages of 18 and 40 years who were given 500 milligrams of vitamin C and 400 IU of vitamin E or a placebo every day for 16 weeks showed that antioxidant supplementation had no effect on insulin sensitivity

And in fact, there've been a lot of these Mendelian randomization studies

That same year the National Institutes of Health indicated that 1.5 percent to 15 percent of the nation is deficient
PCO-02 Safety and Pharmacokinetics Trial [Clinical trial registration NCT02637284]
