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The importance of LCAT in RCT was substantiated in studies showing in vivo that there is enhanced macrophage cholesterol efflux and subsequent cholesterol delivery to the liver and biliary excretion in atherosclerotic Ldlr / mice and cynomolgus monkeys treated with a novel LCAT activator

Am J Clin Nutr 99:408422

In humans, a randomized, double blind, placebo-controlled study demonstrated that verbal memory (as measured by a logical memory passage from the Logical Memory subtest of the Wechsler Memory Scale-Revised) in older adults improves with 1000 mg/d dietary citicoline (CDP choline) supplementation (47)

10.1038/s41388-020-01450-5 86 YangJ