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[Brassicaceae] Sinapine (SI), an alkaloid obtained from Brassica oleracea L

Although this innate immune surveillance is essential for host defence, it poses a critical hurdle for effective drug deposition and cellular uptake in the distal lung 117

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Furthermore, the decline in GFR in advanced stages of CKD leads to the accumulation of drugs and chemical compounds that are typically metabolized or eliminated by the kidneys