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Additionally, urine biomarkers have been shown to be predictive of brain tumor disease burden, in both primary glial tumors [81, 82] and other primary CNS malignancies, including meningioma, ependymoma, medulloblastoma, and hemangioblastoma [81]

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Collectively, the advances summarized above for the different hallmarks of aging highlight the importance of understanding the molecular mechanisms by which each hallmark influences aging pathologies and, more importantly, the functional interconnections between different hallmarks

doi: 10.1016/j.metabol.2007.04.022