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(A) Testicular section of control rat showing seminiferous tubules containing cells of spermatogenic series (SS) and lumen (L) containing spermatozoa

In these assays, CuCl 2 alone showed no activity up to 250 M, whereas Cu 3 -TC-Py consistently produced IC 50 values in the 10-30 M range and Cu 3 -TC-Thio in the 30-60 M range

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Siu F., Bain P.J., LeBlanc-Chaffin R., Chen H., Kilberg M.S

Moreover, it has been shown that increased level of ROS and pro-inflammatory cytokines in brain capillaries may result in blood brain barrio (BBB) permeability and promote the levels of neuroinflammation