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Upon ABA binding, the biosensor undergoes a conformational change, which causes changes in FRET and thereby in FP emission ratio (Jones et al., Reference Jones, Danielson, ManojKumar, Lanquar, Grossmann and Frommer2014)

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10.1002/jps.21924 CrossRef Google Scholar View reference in article 27 DincaA.ChienW.-M.ChinM

At the severe end of this spectrum, persistent energy deficiency may lead to functional hypothalamic amenorrhea (FHA), characterized by suppression of GnRH pulsatility and consequent disruption of ovulatory function, representing a reversible but clinically significant manifestation of energy-conserving neuroendocrine adaptation [90]