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Nevertheless, some studies have noted a heightened likelihood of edema and joint discomfort, which were temporary side effects that correlated with the dosage [30]
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Gallbladder disease In patients with established gallbladder disease, the relative risks and benefits of a cholecystectomy or preventive treatment with ursodeoxycholic acid before starting GLP-1 receptor agonist therapy should be thoroughly discussed

Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, et al
