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483 These areas work in concert to generate and refine motor plans based on sensory inputs and internal models of body dynamics

Redox dysregulation is also linked to protein misfolding by the production of aberrant, non-native disulfide bonds in both mutant SOD1 and TDP-43, which leads to the formation of inclusions and induces toxicity

Astrocyte-to-neuron H 2 O 2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimers disease model

Reducing folate and vitamin B12 uptake in neuroblastoma cell lines diminishes SAM levels and reduces methylation in promoter regions of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and presenilin 1 (PSEN1) genes [173]