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Additionally, they established that according to the WHO definition for MetS, each unit increase in log-transformed IGF-1 concentrations, was associated with a 90.5 % reduction in the risk of MetS [226]

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Other groups of people who have a higher risk include people over age 60, people on certain medications for diabetes, people with Crohns disease, celiac, ulcerative colitis and irritable bowel syndrome and women with a history of infertility or miscarriage

Younger researchers often see subtle effects because their baseline GHK levels remain relatively high