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Excessive levels of ROS are associated with reductions in mitochondrial membrane potential and general mitochondrial malfunction, as revealed by a reduction in the fluorescence of TMRM (Fig

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Im inneren Reaktionsraum der Mitochondrien findet der Abbau der Fettsuren, die -Oxidation, statt

This pre-systemic breakdown drastically reduces the amount of L-arginine that actually makes it into circulation, limiting its impact on nitric oxide production
