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[197] [199] Upon entering the presynaptic neuron, amphetamine provokes the release of Ca 2+ from endoplasmic reticulum stores, an effect that raises intracellular calcium to levels sufficient for downstream kinase-dependent signalling
With a limited sample size available and the low prevalence of these polymorphisms in this NS5A inhibitor-naive population, it is difficult to determine the true impact of such polymorphisms on treatment outcome
