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Heat shock proteins were upregulated in this model, including Hsp25 and Hsp 27

This combined approach effectively disrupted the PD-1/PD-L1 pathway, leading to enhanced pro-inflammatory anti-tumor responses, including heightened infiltration and activity of NK cells and CD8+ cytotoxic T cells, and a decreased frequency of Treg cells

Front Immunol 10:1457 Pincetic A, Bournazos S, Dilillo DJ et al (2014) Type i and type II Fc receptors regulate innate and adaptive immunity

4,5 A key advantage in the study of APAP toxicity is that its human pathophysiology can be effectively reproduced in a mouse model in vivo and in primary mouse hepatocytes