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Description
Notably, IFN- not only facilitates immune system recognition of melanocytes but also inhibits melanocyte proliferation and function, further exacerbating their damage

This duality underlines the necessity of precise molecular characterization of the tumor microenvironment when considering Nrf2 as a therapeutic target (86)

Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)

PLoS One 10 , e0127527 (2015)
