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The compound was originally developed as an antidepressant, and though it failed that indication, it still modulates CNS reward pathways

Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss

A GSL Switch is Unlikely in the Current Climate Despite a recent drive by the Department of Health and Social Care (DHSC) to encourage the reclassification of certain medicines (like those for pain, sleep aids, and skin conditions) to P or GSL status, a switch for injectable B12 is not on the cards