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[PubMed] [Google Scholar] 128.Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S, et al

Loading phases typically use higher doses than maintenance phases

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Abrupt discontinuation or rapid dosage reduction of Alprazolam orally disintegrating tablets after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) [see Drug Abuse and Dependence (9.3)]
