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Role of heat shock proteins 70/90 in exercise physiology and exercise immunology and their diagnostic potential in sports

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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

If mitochondrial dysfunction is a root cause of depression for some people, then it follows that there should be genetic variants in mitochondrial-related genes that are linked to depression