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Indeed, metabolomic studies of an allosteric and reversible inhibitor of GLS, C.968, found that lipid catabolism is activated to compensate for inhibition of glutaminolysis in several cancer cells [59]

Considering a high contribution of sulfation in acetaminophen metabolism, the importance of oxidation in APAP toxicity and of glutathione in APAP detoxification, more studies are needed to establish the relationship between polymorphisms in SULT , GST and CYP genes, and interindividual variability in response to acetaminophen

Hui XIE, Bing YANG, Xin-min ZHOU, Feng-lin SONG, Jian-ming LI, Kang ZHOU, Wen HU and Yi-qun PENG performed the experiments

Nevertheless, our data supports hOCTN2 having a relatively high affinity for Na + , which in the context of physiological Na + concentrations suggests the transporter operates close to saturation