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Portillo JC, Lopez Corcino Y, Dubyak GR, Kern TS, Matsuyama S, Subauste CS
These include inflammatory and autoimmune diseases such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, fibrotic disorders like hepatic, pulmonary, muscle and adipose tissue fibrosis, cancer particularly through TAMs which mediate immunosuppression and facilitate tumor progression and metastasis, metabolic diseases including obesity-associated adipose tissue inflammation, diabetes and its complications, and neurodegenerative conditions such as Alzheimers disease, Parkinsons disease, multiple sclerosis, and stroke, as well as infection ( Figure 4 )

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Gabapentin, tramadol, duloxetine, and mexiletine have demonstrated efficacy in reversing BTZ-induced mechanical pain abnormalities (Yamamoto et al., 2015