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For patients who experience a paradoxical decrease in energy levels, it doesnt mean you should stop taking the B12 but instead decrease your dose by half (so take 2,500mcg every 7 days) or simply take 5,000mcg every 14 days instead

NA generated by gut microbes is also able to maintain a local NAD + /NAM pool that can be a source of circulating NA even in the absence of dietary precursor administration 126,127

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