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Similar to the biochemical properties of MDA, biological 4-HNE also exists in two forms, including free 4-HNE or adducted 4-HNE with proteins, nucleic acids, lipoproteins, and amino acids (152)

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Normally, NPR1 is in an inactive state and forms oxidized oligomeric complexes in the cytosol via intermolecular disulphide bonds

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[65] describes the use of GSH therapy in relieving dyspnea associated with COVID-19 pneumonia in two patients

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