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OLGs have to keep constant contact with axons in order to regulate OPC growth, differentiation, and myelination, which decreases myelin formation and axonal function due to OPC and OLG damage, thus interfering with neuronal connectivity and function

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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Yu T, Zhu C, Chen SC, Gao L, Lv H, Feng RW, et al

The degree of histone lysine Kla has been found to be higher in TAM than in other tissues, implying that Kla plays an important regulatory role in TME, which may provide a new direction for tumor immunotherapy, antiangiogenesis therapy, and targeted therapy