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In this sense, scientific community is searching for new alternative noninvasive techniques or biomarkers for asthma phenotypes identification, treatment monitoring, exacerbations prediction, differential diagnosis of other pathologies with similar symptoms and personalized diagnosis when patients suffer from comorbidities such as rhinosinusitis or other atopic disorders 6,22,23

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D.CeconiC.et al (2024)

Compared to dihydrokavain, lower amounts of urinary metabolites kavain were excreted following its administration but both hydroxylated and ring-opened products were generated