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El cido clorognico, un derivado del cido hidroxicinmico abundante en la alcachofa, inhibe la glucosa-6-fosfatasa (reduciendo la disponibilidad de glucosa para la lipognesis) y modula la transcripcin de PPAR-, suprimiendo los programas de expresin gnica que impulsan la formacin de nuevos adipocitos
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Furthermore, Oxford Academic publications [4] report that disruption of MC4 receptor function produces hyperphagia and obesity phenotypes, further reinforcing receptor-specific mechanisms involved in appetite regulation
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