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[PubMed: 25817945] 113

It is important to bear in mind that IGF-1 serum concentration is 100-fold greater than insulin, however when bound to IGFBPs its biological activity is modulated and in its free-unbound form presents different effects [99, 157]

The addition of the B vitamins caused mild rise in VEGF

However, the body stores B12 reserves in the liver for as long as five years
