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Wong F-C, Xiao J, Wang S, Ee K-Y, Chai T-T

602 The authors identified a new enzyme, TOT1, to be the responsible enzyme, using a combination of biotransformation, in vitro biochemical characterization, and computational modeling (Figure 74)

The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)