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A secondary passive diffusion pathway allows approximately 1% of ingested B12 to be absorbed directly across the intestinal mucosa, independent of intrinsic factor

However, this does not rule out B12 supplementation

In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling

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