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43,44 Nevertheless, one study found 13 novel missense mutations in EGFR exon 19-23 from HCC tissues, 43 and seven of these HCC-derived mutants (K757E, N808S, R831C, V897A, P937L, T940A, and M947T) showed resistant to first-generation EGFR inhibitors

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10.5761/atcs.oa.20-00090 46 GuptaA.RavaliyaV.MishraD.DaniV.SodawalaC.ShahH.et al (2019)