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doi: 10.1038/onc.2017.11 58 BattagliaAMSaccoAPerrottaIDFanielloMCScaliseMTorellaDet al

Additionally, when this version of reduced-BSA homemade B-27 was used, the differentiation medium was supplemented with Insulin-Transferrin-Selenium (ITS) supplement (Gibco, catalog no

PCSK9 has a half-life of around 5 min in plasma and makes up one-third of circulating LDL-C particles [42]

2 Initiation phase: uric acid supersaturation in body fluids and altered physicochemical conditions 2.1 Causes of hyperuricemia and its effects on the local microenvironment The fundamental pathophysiological basis of tophus formation is the persistent elevation of serum uric acid above its solubility threshold, leading to urate supersaturation