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Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity
Targeting novel or multiple sites Targeting novel sites or multiple sites for occupancy of additional binding pockets represents an effective approach to augment the binding affinity of compounds
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Although IL-6 can be beneficial for many aspects of development including myelination, the chronically increased levels that are seen in aged humans and rodents are damaging and pro-inflammatory in nature (Ferrucci et al., 1999
