can l carnitine raise blood pressure l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study | BMC Medicine L-Carnitine Benefits, Sources, and Side

doi: 10.1016/j.ecl.2005.04.009 30 GodowskiPJLeungDWMeachamLRGalganiJPHellmissRKeretRet al

Dec 2002;7(6):456-71

Fatty acids play a critical role in regulating macrophage polarization: saturated fatty acids (e.g., palmitic acid) promote M1 polarization [45, 46], while polyunsaturated fatty acids (e.g., DHA) and n-3 fatty acids (e.g., EPA/DHA) induce M2 polarization [45,46,47]

The title for Figure 4 should be reconsidered as the term "mutually opposite signal modulation" is unclear and/or does not reflect the description to follow. Response: We have replaced the term mutually opposite signal modulation with: amplification of MC3R signaling and attenuation of GHSR1a signaling For Figure 5, the figure legend should clarified if 5-HT2c-GHSR1a dimerization produces reduced Ca++ accumulation with (as appears to be implied by the figure) or without ligand for each receptor. Response: To make it clearer that the 5-HT2C ligand is not required, while the ghrelin ligand is, we have changed the description to read: When dimerized with 5-HT2C, GHSR1a displays a 65% reduction in ghrelin-induced Ca2+ accumulation, with this effect not requiring the presence of a 5-HT2C ligand. Reviewer #2: The review includes an excellent explanation of GSHR1a dimerization with other receptors at the cellular and molecular level and also does a good job of explaining technical aspects of this type of work